Testing drug safety and potential
We develop preclinical models to determine the toxic effects of potential drugs and their metabolism.
Toxicity is one of the most common reasons for manufacturers to withdraw drugs and for health organisations to refuse the approval of new drugs. Sometimes as many as one-third of all drugs fail clinical trials because of toxicity. Current toxicity tests are complicated and some even use chemicals that kill the cells, so that researchers have to use a number of different cell cultures during a study, which affects the result. Another challenge is that although traditional animal and cell models stimulate human disease, they never fully mirror all aspects of human immune response. That is why new, more clinically relevant models have to be created to properly assess the safety and risks of potential drugs for humans.
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